Kane has scored 17 goals in 16 games for Spurs and England this season.
The in-form 24-year-old left the field at Wembley holding his upper leg in the 87th minute after scoring twice in last Sunday's 4-1 win over Liverpool.
With table-toppers Manchester City expected to win away to West Brom too the stakes are huge for both sides even at this early stage of the season.More news: BJP to observe 8th November as anti-black money day
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The Red Devils head into Saturday's game looking to get back to winning ways in the top flight after the disappointment of their shock 2-1 loss to Huddersfield Town last weekend.
"I don't speak about injured players, so don't ask me about Harry Kane", the Portuguese added, before listing United's own lengthy injury list.
Tottenham Hotspur striker Harry Kane has been ruled out of the club's Premier League clash at Manchester United.
Manchester United haven't won the Premier League title since their famous final triumph under Sir Alex Ferguson in 2013.